Long-Term Antidepressant Treatment: Let's Look at the Evidence-Presentation Q&A

Video Transcription

Video Summary

In this video, Andy, a presenter, discusses the challenges of comparing different treatments for depression. He suggests that a point-of-care study, where participants are randomized to different treatments and followed up over time, would provide valuable real-world evidence. The question of how these findings apply to children and adolescents is also raised, and Andy admits that there is limited research in this area. The idea of considering family history and genetics is explored, with Andy mentioning the "Aunt Tilly effect" where a previous positive response to a medication may guide treatment decisions. Long-term use of antidepressants is discussed, with potential side effects such as fatigue, weight gain, and blunted affect. The use of psychedelics as a treatment for depression is mentioned as a promising area of research, particularly for those with PTSD. The role of Brexanilone, a medication used for postpartum depression, and the future of depression treatment are also touched upon, emphasizing the need for personalized and precision medicine.

Keywords

treatments for depression

real-world evidence

family history and genetics

psychedelics as treatment

personalized medicine