Treating Transitional Age Youth with Clozapine
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Expires on May 06, 2025
Credit Offered
1 CME Credit
1 NCPD Credit
1 COP Credit

Treatment of treatment-resistant schizophrenia with clozapine is highly efficacious for adults. There exists a growing body of evidence that clozapine is also efficacious and well-tolerated in transitional age youth, ages 16 to 25 years old for treating treatment-resistant schizophrenia, as well as mania, psychosis, psychotic aggression, and treatment-refractory suicidality. Since clozapine has not been approved for treatment in youth, it is under-utilized in this population and clinicians do not have clear guidelines for obtaining informed consent, whether from young adults or youths’ caregivers. Predominantly a safe treatment, monitoring for side effects in transitional age youth is similar to monitoring in adults, with some important differences in incidence rates and the use of medications for symptomatic side effect relief.  


Recorded webinar, non-interactive, self-paced distance learning activity with post-test.

This presentation was recorded on May 6, 2022.

Learning Objectives

  • Compare treatment with clozapine in transition age youth and adults. 
  • Justify the use of clozapine off label in treating bipolar, psychosis, psychotic aggression, and suicidality in transition age youth.
  • Develop an informed consent process for parents and caregivers of adolescents and young adults.

Target Audience

Nurse/Nurse Practitioner, Pharmacist, Physician Assistant, Psychiatrist, Physician (Non-psychiatrist)  

Instructional Level

Intermediate, Advanced  

Estimate Time to Complete

Estimated Duration: 1.0 hour
Program Start Date: May 6, 2022
Program End Date: May 6, 2025

Ongoing Interdisciplinary Discussion Board

After completing the course, engage with colleagues in the mental health field through SMI Adviser's Webinar Roundtable Topics discussion board. This is an easy way to network and share ideas with other clinicians who participate in this webinar. Access through the discussion tab.

How to Earn Credit

Participants who wish to earn AMA PRA Category 1 Credit, nursing continuing professional development contact hours (NCPD, formerly CNE), or a certificate of participation may do so by viewing the live presentation and completing the evaluation. After evaluating the program, course participants will be provided with an opportunity to claim hours of participation and print an official CME certificate (physicians), NCPD (nurses), or certificate of participation (other disciplines) showing the event date and hours earned.  

Continuing Education Credit


The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The APA designates this live event for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Nurses/Nurse Practitioners

The American Psychiatric Nurses Association is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.  

Faculty and Planner Disclosures


  • Kurt Cousins, MD, MBA is a fellowship-trained double board-certified psychiatrist, practicing general psychiatry and specializing in child and adolescent psychiatry in Austin, TX. He maintains a special interest in treating adolescent substance use disorders and is board-eligible for addiction medicine. Kurt maintains adjunct faculty teaching positions at The University of Texas at Austin, Dell Medical School, Department of Psychiatry as a clinical assistant professor, and in the School of Nursing and in the College of Liberal Arts, Department of Sociology. He is an assistant professor at the Texas A&M College of Medicine. Dr. Cousins reports no financial relationships with commercial interests. 


  • Teri Brister, PhD, LPC, National Alliance on Mental Illness. Reports no financial relationships with commercial interests.
  • John Torous, MD, Beth Israel Deaconess Medical Center. Reports no financial relationships with commercial interests.  
  • Donna Rolin, PhD, APRN, University of Texas at Austin. Reports no financial relationships with commercial interests.  

Accessibility for Participants with Disabilities

The American Psychiatric Association is committed to ensuring accessibility of its website to people with disabilities. If you have trouble accessing any of APA’s online resources, please contact us at 202-559-3900 for assistance.

Technical Requirements

This internet-based CME activity is best experienced using any of the following:

  • The latest and 2nd latest public versions of Google Chrome, Mozilla Firefox, or Safari
  • Internet Explorer 11+

This website requires that JavaScript and session cookies be enabled. Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be:  Adobe Acrobat Reader, Microsoft PowerPoint, and Windows Media Player.

Optimal System Configuration:

  • Browser: Google Chrome (latest and 2nd latest version), Safari (latest and 2nd latest version), Internet Explorer 11.0+, Firefox (latest and 2nd latest version), or Microsoft Edge (latest and 2nd latest version)
  • Operating System: Windows versions 8.1+, Mac OS X 10.5 (Leopard) +, Android (latest and 2nd latest version), or iOS/iPad OS (latest and 2nd latest version)
  • Internet Connection: 1 Mbps or higher

Minimum Requirements:

  • Windows PC: Windows 8.1 or higher; 1 GB (for 32-bit)/2 GB (for 64-bit) or higher RAM; Microsoft DirectX 9 graphics device with WDDM driver; audio playback with speakers for programs with video content
  • Macintosh: Mac OS X 10.5 or higher with latest updates installed; Intel, PowerPC G5, or PowerPC G4 (867MHz or faster) processor; 512 MB or higher RAM; audio playback with speakers for programs with video content

For assistance: Contact for questions about this activity | Contact for technical assistance

Funding for SMI Adviser was made possible by Grant No. SM080818 from SAMHSA of the U.S. Department of Health and Human Services (HHS). The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement by, SAMHSA/HHS or the U.S. Government.
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